Topological descriptions of protein folding
نویسندگان
چکیده
منابع مشابه
Topological determinants of protein folding.
The folding of many small proteins is kinetically a two-state process that represents overcoming the major free-energy barrier. A kinetic characteristic of a conformation, its probability to descend to the native state domain in the amount of time that represents a small fraction of total folding time, has been introduced to determine to which side of the free-energy barrier a conformation belo...
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The Topological Aspects of DNA Function and Protein Folding international meeting provided an interdisciplinary forum for biological scientists, physicists and mathematicians to discuss recent developments in the application of topology to the study of DNA and protein structure. It had 111 invited participants, 48 talks and 21 posters. The present article discusses the importance of topology an...
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Estimation of protein stability is important for many reasons: first providing an understanding of the basic thermodynamics of the process of folding, protein engineering, and protein stability plays important role in biotechnology especially in food and protein drug design. Today, proteins are used in many branches, including industrial processes, pharmaceutical industry, and medical fields. A...
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Monte Carlo simulations of protein folding show the emergence of a strong correlation between the relative contact order parameter, CO, and the folding time, t, of two-state folding proteins for longer chains with number of amino acids, N ≥ 54, and higher contact order, CO > 0.17. The correlation is particularly strong for N = 80 corresponding to slow and more complex folding kinetics. These re...
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For every n, we construct two arcs in the four-punctured sphere that have at least n intersections and which do not form spirals. This is accomplished in several steps: we first exhibit closed curves on the torus that do not form double spirals, then arcs on the four-punctured torus that do not form spirals, and finally arcs in the four-punctured sphere which do not form spirals.
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2019
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1808312116